Several events in TUGS take place up the river. A couple of notable events that have happened in this location are when Zug and Zorran 'accidentally' blocked the river with an old tramper in Trapped, and when Sunshine was trapped in a log jam fire in Up River. The river is also where Sunshine lived before he came to Bigg City Port. Sea Rogue and his uncle lived there too before his uncle was held into ransom by the green-eyed The Pirates to make Sea Rogue steal barges. It is also the new home of Boomer, after he was made into a house boat and now lives in Dun Tuggin'. Uptown, Mittsville, Top Town and the Munitions Factory are all located here.

It is said that many of the planned episodes of season two of TUGS were to be set Up River because it was easier to film there.